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Inhibition of Exo70, an Exocyst Complex Component, Enhances mRNA Delivery Efficiency of Lipid Nanoparticle Ha and Yong Main findings: Co-treatment of mRNA/LNP with Exo70 inhibitor enhances mRNA delivery efficiency in cell lines In vivo results demonstrate mRNA delivery in combination with Exo70 inhibitor highly improves mRNA delivery efficiency Implications: Exocytosis has been recognized as a obstacle for mRNA/LNP delivery This study demonstrates that the inhibition of Exo70, a component of exocyst complex, could be a novel strategy to improve mRNA delivery of LNP system To view or add a comment, sign in Clinical Fact Of The Day Did You Know Macular Degeneration Treatment May Soon Swap Monthly Eye Injections for Simple, Needle-Free Eye Drops

This paper aims to elucidate the biochemical characteristics of PNC-27 and explore its potential therapeutic applications in the field of oncology

doi: 10.1016/j.gde.2014.06.005 102 NilssonEESkinnerMK

If you freeze a 5mL vial and thaw it six times over three months, you've introduced cumulative damage that refrigeration alone would have avoided

Dose adjustments may be necessary based on the severity of kidney impairment, and consulting with a physician is important to ensure safe and effective use