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A further investigation has shown that serum concentrations of leptin and adiponectin, two key hormones of the energy metabolism, are strongly and independently of the BMI associated with the ALS risk

Increasing research efforts have focused on stroke-induced changes in remotely connected regions, including cortical areas in the contralesional hemisphere, thalamus, and the cerebellum, since stroke can disrupt neuronal function within minutes and extend this effect to connected areas [88, 89]