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Nitric Oxide 5:6271 Misera HP, Fridovich I (1972) The role of superoxide anion in the autooxidation of epinephrine and a simple assay for SOD

282,283 Trimethylamine N-oxide, which is secreted by Clostridium species, can activate protein kinase RNA-like endoplasmic reticulum kinase-mediated endoplasmic reticulum stress, increasing antitumor immune responses and improving the efficacy of immunotherapy for triple-negative breast cancer

4.1 Key molecular pathways ROS-induced in NSCs 4.1.1 NRF2 signalling Nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as it represents the master regulator of the cellular defense against oxidative stress

The therapy can dangerously deplete essential minerals like zinc, calcium, and magnesium, requiring supplementation and weekly blood monitoring during treatment