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25 As the first enzyme in the transsulfuration pathway, CBS has a SAM regulatory site and mutation at this site results in homocystinuria, 30 which is closely associated with cancer

On the other hand, for the L-NAME retrobulbar applicationinduced retinal ischemia model and BPC 157 therapy in rats, we should emphasize the point that animal studies per se may be cautious regarding their results, although the role of an animal model is indispensable (Vestergaard et al., 2019)

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Blood tests on admission showed neutrophil leukocytosis at 18.510 9 /L, elevated C-reactive protein at 210mg/L and bicarbonate of 24 mmol/L

The effluent was alternatively connected to an ESI-triple quadrupole-linear ion trap (QTRAP)-MS