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Neurosci Lett 72: 189193

Smith RP, Easson C, Lyle SM, et al

Bibcode:2024NatCo..15.1547A

First, at the mechanistic level, single-cell spatial transcriptomics and metabolomics should be used to map ferroptosis pathways in nigral dopaminergic neurons, astrocytes, and microglia, with emphasis on the interplay between NCOA4-mediated ferritinophagy and -synuclein degradation, to build a dynamic model linking iron dysregulation, proteotoxic stress, and cell death