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This significant decline was reversed upon treating the rats with either manuka honey (2.5 gm/kg) or ranitidine (30 mg/kg) resulting in a significant increase of gastric mucosal GSH content (~250%) as compared to ulcer control group ( P = 0.000) (Figure 5)

A mitochondrial DNA sequence variation affecting a subunit of NADPH-ubiquinone reductase (complex 1), a component of the electron transport chain responsible for generating superoxide, has also been associated with schizophrenia patients and with increased superoxide levels in post-mortem brain samples (Marchbanks et al

Variability in plant origin, harvesting conditions, and extraction methods can significantly alter phytochemical profiles, underscoring the importance of standardized manufacturing practices for clinical and translational applications (6)

Second, the role of metabolic reprogramming in ferroptosis highlights how sustained mechanical stress and inflammation reshape lipid, amino acid, iron, and glucose metabolic pathways in OA chondrocytes and synovial cells

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& Brocklehurst, K