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EGFR also induces ERK2 to phosphorylate PKM2 at Ser 37, which allows peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) to bind to PKM2, prompting PKM2 to translocate to the nucleus, upregulating lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1) expression and promoting the Warburg effect (Yang et al., 2012b)

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Surgery is reserved for large orbital tumors in which the patient has no useful vision, when the cornea is exposed, or if there is proptosis.39 Malignant Peripheral Nerve Sheaf Tumor MPNST (or neurofibrosarcoma) is a type of sarcoma that is thought to be derived from Schwann cells

2012;142(6):13031313.e1 Chien, R.-N., Lin, C.-Y., Yeh, C.-T., and Liaw, Y.-F

Mild side effects like temporary discomfort at the IV site, headache, or nausea can occur