is glutamine related to glutathione Basis for the use of L-glutamine treat sickle cell disease. Intense Targeting Glutamine Induces Apoptosis: A

[2]Current Patent Assignee: NEW SOUTH INNOVATIONS - US2006/166208, 2006, A1 Location in patent: Page/Page column 16

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2.5 Disrupted proteostasis and autophagy-lysosomal dysfunction The autophagy-lysosomal pathway (ALP) and ubiquitin-proteasome system (UPS) are critical for degrading misfolded proteins

Notably, the #14 mutant produced 1.98 g/L of glutathione with a volumetric productivity of 26.36 mg/L/h in the molasses/CSL-based medium, showing efficiency comparable to genetically engineered strains