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Lambs 0.5mL at tailing or weaning Sheep 1mL pre-lambing Calves 2 - 3mL from 2 months of age Cows 4 - 6mL pre-calving Cobalt deficiency in soil and/or pasture leads to a lack of Vitamin B12 in body tissues of stock which, subsequently, may have poor growth rates and ill thrift, particularly in young animals Before treatment, establish pasture cobalt levels and/or Vitamin B12 status of stock Treatment is likely to last only 4-6 weeks if liver storage levels of Vitamin B12 and pasture levels of cobalt are low Treatment of pregnant ruminants should benefit newborn animals, particularly when treated in latter stages of pregnancy Supplementation of young ruminants should begin at or before weaning

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The consequences of B12 deficiency on the lipid metabolism however remains under-researched better understood are the effects on the nerves

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NNMT expression is usually elevated under metabolic stress and altered mitochondrial activity (36, 37), which may represent a strategy for reacting to oxidative stress