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IDO activity commonly leads to the suppression of the immune system [126]

Using ADSC-Exo as a carrier, researchers engineered exosomes targeting M2-type microglia (M2pep-ADSC-Exo) to explore their therapeutic potential in ischemic stroke (Wang et al., 2024)

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Nuclear factor-erythroid factor 2-related factor 2 (NRF2), allowing NRF2 to translocate to the nucleus and coordinate with the transcriptional co-activator, peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1), to drive mitochondrial biogenesis [142]