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Phase I study of 6-diazo-5-oxo-L-norleucine (DON)

Part of the US population is exposed to haloalkenes from such sites and in the workplace (Wu and Schaum, 2000) and possibly through recreational abuse (Marjot and McLeod, 1989)

On admission, her heart rate was elevated to 120 beats per minute

Disclosures: Takeshi Chida: The Chemo-Sero-Therapeutic Research Institute: Grant/Research Support, Masahiko Ito: Nothing to Disclose, Kazuyoshi Ohta: Nothing to Disclose, Hidenao Noritake: Nothing to Disclose, Kazuhito Kawata: Nothing to Disclose, Tetsuro Suzuki: Nothing to Disclose 511 DIRECTLY OBSERVED DAA THERAPY COMPRISING EXTENDED DISPENSATION INTERVALS AS A UNIQUE APPROACH TO STREAMLINED HCV MICROELIMINATION FOR PWID Caroline Schwarz 1 Angelika Schtz 2 David Bauer 1 Enisa Gutic 1 Thomas Reiberger 3 Hans Haltmayer 2 Michael Gschwantler 1 , 1 Klinik Ottakring, Vienna, Austria, 2 Suchthilfe Wien gGmbH, Vienna, Austria, 3 Medical University of Vienna Background: Directly observed therapy (DOT) with direct-acting antivirals (DAA) alongside opioid agonist therapy (OAT) is an effective hepatitis C (HCV) microelimination strategy for people who inject drugs (PWID)

Critical step: Direct the water stream against the inside wall of the vial, not directly onto the powder

Grover S, Srivastava A, Lee R, Tewari AK, Te AE