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10.1038/s41467-023-35990-7 62 ZhuangZ

The main sources of sulfur-rich foods are cruciferous vegetables and allium vegetables like onions, garlic, shallots, and leeks

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The mechanisms likely involve immune modulation (microglia in ALS can adopt a neurodegenerative phenotype that might be restrained by microbial signals) and metabolic support (providing nutrients like nicotinamide or SCFAs to neurons and glia) [214, 218]

These hypotheses have been validated in preclinical models,76 77 98 103 112116 and such agents are now advancing into clinical trials (eg, NCT04330664)