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While certain natural products have shown promising results in in vitro models, attributing them with specific therapeutic relevance, especially in in vivo ovarian reserve preservation, remains speculative without clearer mechanistic evidence (Supplementary Appendix 4)

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The generation of high FFA flux and cellular trafficking may be correlated with the associated downstream events of NAFLD pathogenesis, such as inflammation, high ROS, fibrosis, and liver damage, while metabolic abnormalities and the gut microbiota aggravate the disease progression

However, serious side effects such as allergic reactions or heart failure in individuals with heart disease are rare but possible

Murthy SB, Patnana SV, Xiao L, Rohren E, Hofstetter WL, Swisher SG , Liao Z, Lee JH, Bhutani MS, Macapinlac HA, Wang X, Ajani JA