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Proton leak, the process by which protons cross the mitochondrial membrane without contributing to ATP synthesis, can be an adaptive response to mitigate the detrimental effects of excessive ROS production (Nishikawa et al

Lower concentration means larger injection volumes, which are easier to measure precisely

Unlike proposals for plants and yeast, the HSC20 transfer complex was shown to be required for FeS acquisition in complex I, which contains eight FeS clusters, and also in complex III, which contains a single [2Fe2S] cluster (Maio et al

Both patterns appear in the research framing

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Feigin, Stephen S