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We identified all patients with a diagnosis of variceal bleed followed by transfusion of FFP or platelets or cryo within 72 hours of diagnosis (this was noted as index event) and analyzed outcomes data for the following 6 months

By interfering with this hyperactivated process, P140 reduces the presentation of self-antigens to T cells, effectively dampening the autoimmune drive at one of its key control points

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

NRF2 in Amyotrophic Lateral Sclerosis ALS is the most common motor neuron disease in adults and estimates have reported that 31,000 patients live with ALS in the US, where on average 5,000 new patients are diagnosed annually (Mehta et al., 2023)

Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

doi: 10.1006/bcmd.2002.0556 39 RuperezAIOlzaJGil-CamposMLeisRMesaMDTojoRet al