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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

Sepesi B, Feldman H, Walsh GL, Rice, DC, Roth JA , Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Gibbons DL, Heymach JV, Vaporciyan AA, Swisher SG, Cascone T

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[32] Another player assisting ferroportin in effecting cellular iron export is GAPDH