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thus, there was no indication of an underlying BRAF V600E mutation

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Number of regional lymph nodes involved, with distinction of clinically occult and clinically apparent

Any suspicious lesion and/or significant change should be considered for biopsy, preferably by excision with conservative surgical margins (2 mm) providing adequate samples for histopathological evaluation.3,8 Non-surgical alternatives such as topical 5-fluorouracil, systemic isotretinoin, topical tretinoin with or without hydrocortisone, topical imiquimod and laser ablation are not effective or safe for the removal of suspicious lesions and are not recommended.8,52

Studied in laboratory settings for receptor interaction and peptide stability