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In response to low-temperature stress, GST s can catalyze the reaction of GSH with membrane lipid peroxides, reducing the damage that low-temperature stress causes to the cell membrane structure [7, 31]

doi: 10.1073/pnas.210395797 99 PearsonG.RobinsonF.Beers GibsonT.XuB.-e.KarandikarM.BermanK.et al

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Although regulating the MUFA/PUFA ratio by lactate through the SCD1/ASCL4 pathway does affect membrane lipid peroxidation sensitivity, this protective effect against ferroptosis may be more highly dependent on the state of the intracellular antioxidant system (83)

10.3390/cancers13174375 100 ShuX.ZhanP

In addition, we observed in histology that there was an increase in inflammatory cells, necrosis, hemorrhage and hyperemia