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[77] [78] In healthy humans, the half-life of PPIs is about 1 hour (9 hours for tenatoprazole), but the duration of acid inhibition is 48 hours because of irreversible binding to the H,K-ATPase

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doi: 10.1016/j.cmet.2011.02.010 117 HuiXYGuPZhangJLNieTPanYWuDHet al