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10.1038/nrrheum.2016.85 118 Van SpaendonkH.CeuleersH.WittersL.PatteetE.JoossensJ.AugustynsK.et al (2017)

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Gumusoglu SB, Chilukuri ASS, Santillan DA, Santillan MK, Stevens HE

Epidemiology: High levels of vitamin B12 were found in: Causes: Excessive supplementation (a direct increase in plasma vitamin B12 by excess intake or administration) Increased release of vitamin B12 from tissue stores (liberation from an internal reservoir): Solid tumors (especially hepatic or hematologic malignancies) Liver metastases Increased binding proteins: 7 Excess production: Liver disease (e.g., hepatitis, cirrhosis, hepatocellular carcinoma) damaged hepatocytes release haptocorrin (transcobalamin I) and B12 into circulation Myeloproliferative disorders these increase granulocyte production, which leads to more haptocorrin (transcobalamin I/III), a B12-binding protein produced by proliferating myeloid cells

Omega-3 supplements can potentially improve outcomes by reducing the overwhelming inflammatory response found in sepsis (Lu et al., 2017)

CJC-1295 may cause vasodilation, flushing, or changes in heart rate for some people