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On the other hand, modulating CD38 enzymatic activity may serve as a NAD boosting therapy for aging and metabolic diseases (Figure 1)[1-4, 6, 19, 36, 39]

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134 In cancer cells, OXPHOS increases reactive oxygen species (ROS) production and leads to oxidative stress, activation of p53 signaling and DNA damage, particularly when combined with chemotherapy or other cancer therapies

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A significant increase in the concentration of oxidants suggests a clear intensification of the oxidative system and weakening of the antioxidant system (27)