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For example, ROS produced by macrophages can induce the generation of Tregs [238], while mice lacking neutrophil cytosolic factor 1, even with low ROS levels, have more responsive Tregs than wild-type mice [168]

Allaouchiche B

Clin Endocrinol (Oxf) (2011) 74:11824

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Both reports confirm the expert opinion recently reported by the author where lactate (Warburg effect) increases the steady-state ROS condition in cancer cells 4 and the published work that antioxidants are the guardians and gatekeepers against oxidative stress-induced hepatocarcinogenesis 24