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Reasons for increased needs in athletes: stress related to physical demands (Yes, training is stress on the body!) biological adaptations increased turnover (athletes use more vitamins) genetics reduced absorption Early detection of deficiency can be difficult to recognize because symptoms overlap with many other conditions and are normalized in athletes

Neurological Damage: Prolonged vitamin B12 deficiency, especially if left untreated, can lead to irreversible neurological damage, including demyelination of nerve fibers in the brain and irreversible neurological deficits

THR-123 (LT-1090-11, LifeTein) was labeled with Fluorescein amidites (FAM), which imparts green fluorescence

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29: 902910 Giamp C, Patassini S, Borreca A, Laurenti D, Marullo F, Bernardi G, Menniti FS, Fusco FRJNod (2009b) Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntingtons disease

doi: 10.1016/j.semcdb.2017.05.023 6 SahaSKLeeSBWonJChoiHYKimKYangGMet al