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Therefore, ROS production upon antigen stimulation of TCR promotes TCR signaling and transcriptional activation of IL-2 ( Figure 2 )

2.3 Dosing in Patients Taking Rufinamide Patients stabilized on rufinamide before being prescribed valproate should begin valproate therapy at a low dose, and titrate to a clinically effective dose [see Drug Interactions (7.2) ]

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