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Exposure to aspartame at 10 M increased intracellular ROS (measured as DCDFA fluorescence) and also depleted intracellular glutathione (GSH)

Chariyalertsak, S., Sirisanthana, T., Supparatpinyo, K., Praparattanapan, J

Ferroptosis, an alternative form of cell death to apoptosis, is characterized by elevated levels of iron-dependent lipid hydroperoxide accumulation and is not influenced by substances associated with other recognized cell death pathways

This was confirmed by the model and the model also predicted that arsenicals in the liver will decrease by 19% and arsenicals in other body stores by 26% in these same individuals

Palaniyappan L, Liddle PF

A Novel Redox-Responsive Ursolic Acid Polymeric Prodrug Delivery System for Osteosarcoma Therapy