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While these 2 trials have generated considerable optimism about a future role of GLP1 agonists as disease-modifying both in the PD research and patient community, a recent placebo controlled phase 3 trial of exenatide in 215 subjects with early PD on symptomatic therapy failed to meet its primary endpoint and found no significant difference in MDS-UPDRS part III OFF-scores at 96 weeks [187]