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Martin (University of California, Berkeley) for the plasmid that expresses the Rpn11Rpn8 dimer, E

More importantly, auranofin completely blocked the ability of etomoxir to alleviate ER stress (Figure 5D)

Biotransformation is mainly done through what is called the phase I and phase II pathways in the liver

Sonika et al., 2017)

Second, protein aggregates can trigger immune responses, potentially causing injection site reactions or, in rare cases, the development of anti-drug antibodies that neutralize future doses