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( D E )

The chord plot demonstrates the nine pathways with the lowest p-values (Figure 7C), and the upregulated genes with the largest multiplicity of differences on these pathways were Trdn, Bmp5, Ptgfr, Thsd4, Ryr1, Fn1, and Inhca

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The changes in DNA methylation primarily involve pro-inflammatory mechanisms, such as MHC class II antigen presentation, suggesting a pivotal role of neuroinflammation in the progression of MTLE (231)

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In vitro studies in prostate cancer cells with PROTAC UBX-390 (DC 50 = 2.4 nM, D max = 96%) demonstrated that it has a prolonged degradation activity superior to that obtained with predecessor PROTACs, such as ARV-110 (DC 50 = 3.1 nM, D max = 96%) which is currently in clinical studies