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Notably, cGAS- and BAX-dependent microglial senescence was exacerbated by the combined presence of the APOE4 allele and the TREM2 R47H variant, indicating both associated with increased risk and earlier onset of Alzheimer's disease and their potential role as upstream modulators of AD pathogenesis (Carling et al., 2024)

Arginine is also an essential component of the urea cycle, where the enzyme arginase catalyzes its conversion to ornithine, thereby generating urea

doi: 10.1007/s11064-008-9593-0

Abnormal metal ion distribution has been implicated in various forms of RCD, including ferroptosis [18,19,20,21]

P., De Mey, J

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