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Further, AChE binding to the non-amyloidogenic form of -amyloid peptide (A) appears to facilitate a conformational shift to the amyloidogenic form ( , Donepezil , Rivastigmine , and Galantamine ) which will go generic in the near future ( (Memantine HCl) in 2004, an N -methyl-d-aspartate (NMDA) receptor antagonist designed to limit glutamate excitotoxicity and intended to treat moderate to severe AD patients ( There are many possible reasons for the lack of an effective therapy for AD including the complexity of the disease process and the resulting inability to identify reliable biomarkers

HIF-1a is known to be involved in cellular responses to hypoxia and oxidative stress

doi: 10.1038/nature12040

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Neuron 44(4):601607