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Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease

[38] The final results of the TACT trial were published in November 2012

We hypothesize that GSH increases during cognitive effort or sustained cognitive effort to reduce the endogenous ROS

Mitochondrial dysfunction is increasingly recognized as a contributor to neuropathy, particularly in diabetic and chemotherapy-induced forms where mitochondrial damage in dorsal root ganglion neurons precedes and contributes to axonal degeneration

Individuals experiencing brain fog may also report distractibility, forgetting intentions (e.g., the reason for entering a room), and struggling to switch between tasks [7]

As previously described, DTP cells shift toward increased dependence on mitochondrial oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO), and enhanced antioxidant responses