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Inhibition of the glutamate forming enzyme glutamate carboxypeptidase II (GCP II), may help prevent both peripheral and central nervous system damage during chemotherapy and has been proposed as a possible treatment for amyotrophic lateral sclerosis (ALS), stroke, and even Multiple Sclerosis plus other neuropsychiatric diseases (Rahn et al, 2012)

It is generally accepted that the cysteine S -conjugate S -(1,2-dichlorovinyl)-L-cysteine is the penultimate nephrotoxicant

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10.1002/jbm.a.31238 132 KatzJ

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Its not a clear-cut winner over tirzepatide in head-to-head databut it doesnt need to be