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Although speculative, metabolites in the kynurenine pathway are critical immunomodulators, which contribute, along with arginine (one of the most affected pathways identified herein), to immunosuppressive activity of dendritic cells (48) and to CD8 + T cell suppression in breast cancer (49, 50)

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liver failure: OR = 3.876, SLD: OR = 1.555)

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