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AOD-9604 is an intellectually interesting compound whose mechanism is well-characterized in preclinical models, whose safety profile is genuinely clean, and whose clinical program ultimately did not deliver

While the absorption rate for oral resveratrol is as high as 75%, almost all of that is broken down through first-pass digestion and never reaches any target tissues outside the evenly spread delivery from normal blood flow.2 And unlike certain drugs whose uptake can be improved by the presence of food especially fatty foods food intake appears to blunt the absorption of resveratrol.3 The most common approach to solving the resveratrol bioavailability conundrum has been to micronize it

Inflammation & Redox Balance*

Yasuhara T, Shingo T et al (2004) Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinsons disease

When this happens, the digestive tract has a large opening which causes the stomach to be filled with gastric fluids, and this can lead to a dangerous infection

J Biol Chem 279:3567135678