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10.1016/j.cmet.2019.06.009 Cell Metab

Nat Neurosci 13 (11), 1396403 (2010)

It is noteworthy that cystine starvation has been observed to induce -glutamyl-peptide accumulation via the NFE2-like BZIP transcription factor 2 (NRF2)-glutamate-cysteine ligase catalytic subunit (GCLC) axis, thereby preventing ferroptosis in a GSH-independent manner in non-small cell lung cancer (NSCLC) cells [44]