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doi: 10.1192/j.eurpsy.2022.491 [DOI] [Google Scholar] 85.Yudiarto FL, Muliadi L, Moeljanto D, Hartono B

The major risk factors for Alzheimers disease: Age, sex, and genes modulate the microglia response to abeta plaques

It's a method that moves beyond simple observation, pushing towards a more holistic understanding of biological systems

287 Consistent with this, upon VDR siRNA knockdown, the downregulation of TJ proteins, including CLDN1, ZO-1/2, and E-cadherin, and the reduction of TER were revealed, which were relieved by 1,25-dihydroxyvitamin D3 [1,25(OH) 2 D 3 ], suggesting the role of VDR-mediated vitamin D signaling in the regulation of TJs

Each method has its own set of pros and cons based on convenience, cost, and effectiveness

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