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10.1016/j.tips.2024.08.007 38 FengX.LingL.ZhangW.LiuX.WangY.LuoY.et al (2020)

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[7] The study also demonstrated that older persons (mean age, 61 years) have higher levels of CD38 gene expression than younger adults (mean age, 34 years)

Until larger, longitudinal, and intervention studies clarify directionality, clinicians should treat bona-fide B12 deficiency for its hematologic and neurologic harms while investigatingand not assuminga possible cancer connection