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Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

Bunse M, Pfeilschifter J, Bluhm J, Zschummel M, Joedicke JJ, Wirges A, et al

Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, et al

Thioredoxin system in insects: uncovering the roles of thioredoxins and thioredoxin reductase beyond the antioxidant defences

Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons

An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility