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In experimental models it modulates angiogenesis (upregulating VEGF/VEGFR2 and the nitric oxide pathway), reduces pro-inflammatory cytokine signaling, supports fibroblast migration and collagen synthesis for connective-tissue repair, and influences gut-barrier integrity and neural pathways mechanisms that span musculoskeletal, gastrointestinal, and neurological tissue in preclinical research

Despite the different pathways leading to cell death, there is a significant crosstalk between them, which depends on the cellular and tissue context, such as after PD lesion stimuli in animal models (Hartmann et al., 2001

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We will be tracking these developments closely in the coming months.