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Rating: 4.7641 (15 reviews)

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Description

NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2M) and can selectively bind to NNMT substrate binding site residues

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SCFAs produced by microbiota affect mitochondrial function, for example, the lack of butyrate led to a significant reduction in nicotinamide adenine dinucleotide (NAD), resulting in autophagy in germ-free mouse colon cells [30]

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