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identified that specific gut microbes inhibit remodeling-associated cytokines (IL-4, IL-5, IL-9, IL-13) through SCFA production, mitigating airway wall thickening ( Lactobacillus rhamnosus (Lr) administration reduced leukocyte infiltration, bronchial hyperreactivity, and remodeling markers (IL-4, IL-5, IL-13, STAT6, GATA3, IL-17, IL-21, IL-22, STAT3, RORt) in asthma-COPD overlap syndrome (Vasconcelos et al., 2023)

10.1080/10717544.2020.1760960 31 HashizumeR.OzawaT.GryaznovS, M.BollenA, W.LambornK, R.FreyW, H.et al (2008)

However, its effects on homeostasis are complex and highly dependent on the type, intensity, duration, and recovery status of the exercise [22, 23]

Certain painkillers (NSAIDs), antibiotics like tetracyclines, antimalarial drugs, some chemotherapy drugs, and even some heavy metals are common causes of dark lips induced by medications 2

2628 Recent publications critiquing ELISA-based 8-OHdG methods suggest that ELISA-based values tended to be higher values than gold-standard LC/MS-based measurement