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Oral formats of SLU-PP-332 therefore have no published evidence of producing the systemic ERR agonism observed in the IP-route mouse studies

Peripheral peptide hormones are released postprandially and travel in the circulation to bind to their receptors in the homeostatic regulatory centers in the CNS, notably the arcuate nucleus (ARC) of the hypothalamus and the dorsal vagal complex (DVC) in the brainstem medulla

For example, researchers cross-linked TGF- to the surface of SPION particles through carbodiimide and applied an external AMF to generate a thermal effect, thus achieving AMF-responsive release [384]

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