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Turner et al

We address each of these criticisms as discussed in the following paragraphs

MIC values were taken as the first value at which no turbidity or sediment was observed at the bottom of the well after 18 2 h of bacterial growth

To bridge the preclinicalclinical gap, three concrete translational pathways are proposed: (1) Biomarker validation: Conduct prospective human cohort studies to verify preclinical biomarkers (e.g., GSDMD-NT for pyroptosis, HMGB1 for inflammation, MDA for lipid peroxidation, ferritin for ferroptosis) in serum and liver biopsies of EHS/CHS patients, establishing their diagnostic (early liver injury detection) and prognostic (MODS progression prediction) utility [59, 89]

Saliva serves as a reflection of the bodys state across various hormonal, immunological, toxicological, and infectious conditions, functioning as a biological indicator and an effective means for tracking both oral and systemic well-being