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The mitochondrial matrix contains Grx5, an enzyme involved in the last stages of iron/sulfur cluster synthesis (Ramos-Alonso et al., 2018

Of these options, several showed early promise but failed in either safety or efficacy trials

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Similarly, ferulic acid (FA)-based prodrugs have demonstrated LAT1-specific binding, enabling BBB penetration and cellular uptake

For the scenario of "Erythropoietic Protoporphyria (EPP)," research data suggests Melanotan-1 may be more relevant

Green et al., 2020)