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6 The impact of the disc microenvironment on MSCs and disc progenitor cells As the soil upon which seed cells depend for survival, the impact of the microenvironment on the function of mesenchymal stem cells in disease states and during treatment is increasingly garnering attention

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doi: 10.1007/978-3-030-54719-6_3 222 TwaijB.HasanM

The cereblon-based PROTAC 121 , targeting sirtuins (Sirt) histone deacetylases, was shown to selectively degrade and inhibit target activity (IC 50 value of 0.25 M), thereby inducing downstream -tubulin hyperacetylation

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