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The review also identified a scarcity of longitudinal incidence data, with only one relevant study reporting a baseline incidence of approximately 8% among individuals aged 4892 years

The molecular basis of the enzymatic regulation remained unknown until 2018

While injectable forms have safety concerns and are not recommended without medical supervision, topical formulations have shown promise in clinical trials and cosmetic studies when properly formulated

The process of pyroptosis mainly involves the caspase-1-dependent pathway (classical pathway) and the caspase-1-independent pathway (non-classical pathway), and is closely related to the secretion and activation of the pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, which play an important role in inflammatory response and immune defense through the release of inflammatory mediators and the recruitment of immune cells (103105)

[11] Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B

Int J Mol Sci 22(13):6923 Matthews HK, Bertoli C, De Bruin RA (2022) Cell cycle control in cancer