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Russo, 2013

Acetyltransferases such as KAT5 and p300 increase ATG transcription by opening chromatin, whereas HDAC1/2 and SIRTs suppress autophagy in basal states

In addition, exercise activates the AMPK signaling pathway, accelerating fatty acid -oxidation, effectively reducing hepatic lipid accumulation, and improving blood lipid profiles, as evidenced by increased HDL levels and decreased LDL levels (Bekheit et al., 2025)

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