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However, a prolonged half-life of more than 4 h can occur in individuals that either consume an overdose of APAP or that exhibit a clinical history of hepatic injury or chronic liver disease ( As APAP hepatotoxicity is the most common cause of acute liver failure requiring liver transplantation, a better understanding of the molecular events contributing to APAP hepatotoxicity may provide novel opportunities for intervention

Aryl hydrocarbon receptor activation in chronic kidney disease: role of uremic toxins

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Together, these data and other findings suggest that if NMN treatment leads to increased carbonyl reductase activity, this does not translate into an increased risk of cardiac dysfunction

Further bioinformatics analysis suggested that patients with low SLC25A39 expression might exhibit heightened sensitivity to immunotherapy

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