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In addition to these conventional sites of mitochondrial ROS generation, it has been recently reported that the branched-chain 2-oxoacid dehydrogenase (BCKDH) complex in mitochondria can produce superoxide and H 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)

Org Electron 16:7786 Schafer FQ, Buettner GR (2001) Redox environment of the cell as viewed through the redox of the glutathione disulfide/glutathione couple