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Some studies demonstrated that ApoE4 homozygotes have a very high risk for Amyloid-related imaging abnormalities (ARIA) with both aducanumab and lecanemab and many providers do not administer these medications in ApoE4 homozygote carriers for this reason (Sperling et al., 2012

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In the next section, we will focus on the associations of m6A with apoptosis, autophagy, pyroptosis, oxidative stress, inflammatory response, lipid metabolism, and ferroptosis, which may provide new insights into the pathogenesis and management of CVDs (see details in Figure 2 and Table 1)

GSTA4 mRNA expression was significantly higher in the IA group than in the control group ( p .05, Figure 3C)